Basic biology of malignancy

Cancer biology: Extracellular proteinases in malignancy

Secreted, matrix-degrading proteinases have been viewed as contributing to tumor metastasis. A recent study indicates that the gene for one of these enzymes, the matrix metalloproteinase stromelysin-1, can actually cause cancer when expressed in transgenic mice.

Basic methods in Theoretical Biology

Some Basic Aspects of HLA-G Biology

Human leukocyte antigen-G (HLA-G) is a low polymorphic nonclassical HLA-I molecule restrictively expressed and with suppressive functions. HLA-G gene products are quite complex, with seven HLA-G isoforms, four membrane bound, and other three soluble isoforms that can suffer different posttranslational modifications or even complex formations. In addition, HLA-G has been described included in ex...

Basic biology of new developments in biotechnology.

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Basic Biology of Mesenchymal Stem Cells.

A population of stem cells variously named mesenchymal stem cells, marrow stromal cells or more recently, in an attempt at standardization, mesenchymal stromal cells, but all luckily abbreviated MSC, has emerged as a highly interesting candidate for cellular therapies [1]. These cells have been known for a number of years to be key regulators of hematopoiesis within the bone marrow stroma [2]. ...